Treatment of Vitiligo







General Measures

  • Sun Protection: Use high SPF sunscreen and wear protective clothing to prevent sunburn and minimize contrast between affected and unaffected skin.
  • Cosmetic Camouflage: Makeup, dyes, and stains can help disguise vitiligo patches.
  • Avoid Skin Trauma: Prevent cuts, abrasions, and other injuries to minimize the risk of new patches developing.

Medical Treatments

  • Topical Corticosteroids: Effective for treating vitiligo on the trunk and limbs but should be used with caution due to potential side effects like skin thinning.
  • Calcineurin Inhibitors: Tacrolimus and pimecrolimus are preferred for sensitive areas (face, neck, armpits) as they do not cause skin atrophy.
  • Vitamin D Analogues: Often used in combination with other treatments for better efficacy.
  • JAK Inhibitors: Ruxolitinib cream has shown promise in treating non-segmental vitiligo.


Phototherapy involves exposing the skin to controlled UV light:

  • Narrowband UVB: Effective for widespread vitiligo, often used in combination with topical treatments.
  • Excimer Laser: Targets small areas, particularly useful for facial vitiligo.

Systemic Treatments

  • Oral Corticosteroids: Used in short bursts to control rapid disease progression.
  • Immunosuppressive Agents: Methotrexate and cyclosporine are sometimes used to stabilize active vitiligo.

Surgery may be considered for stable vitiligo:

  • Skin Grafts: Transplanting healthy pigmented skin to affected areas.
  • Cell Transplants: Transferring melanocyte cells to depigmented areas.

Depigmentation Therapy

For individuals with extensive vitiligo, depigmentation of remaining pigmented skin may be an option to achieve a uniform skin tone. This is a permanent treatment and involves applying a depigmenting agent over several months to remove residual pigment.

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