Overview
Causes of Atopic dermatitis
The exact cause of atopic dermatitis is not fully understood, but it is believed to result from a combination of genetic and environmental factors. Key causes and risk factors include:
Genetic Susceptibility: Atopic dermatitis often runs in families, indicating a hereditary component. Alterations in genes that are important for maintaining a healthy skin barrier, such as the filaggrin gene, have been closely linked to the development of eczema.
Environmental Triggers: Common environmental factors include contact with soaps, detergents, chemicals, allergens, and certain bacteria and viruses. Exposure to these substances can irritate the skin and trigger inflammatory responses.
Immune System Dysfunction: People with atopic dermatitis typically have an overactive immune system that responds aggressively to environmental triggers, leading to chronic inflammation and skin barrier dysfunction.
Allergies and Asthma: Atopic dermatitis is often associated with other atopic conditions such as hay fever, asthma, and food allergies.
