The Inherited Barrier Defect of Atopic dermatitis

The Inherited Barrier Defect
Causes of Atopic dermatitis

Overview

The Immune System’s Role

The Inherited Barrier Defect

The Microbiome’s Role

Role of Infections

Allergens and Eczema

Stress and Climate

Studies indicate that inflammation in atopic dermatitis stems from inherited abnormalities in the skin barrier, particularly in filaggrin expression. Abnormalities in filaggrin, a protein crucial for skin integrity, are associated with severe and persistent eczema.

In atopic dermatitis, there’s often an imbalance in T Helper lymphocytes, with an excess of Th-2 cells. These cells, along with associated chemical messengers like cytokines, contribute to barrier dysfunction and increased susceptibility to irritants and allergens.

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