The Inherited Barrier Defect
Causes of Atopic dermatitis
Overview
Role of Infections
Allergens and Eczema
Stress and Climate
Studies indicate that inflammation in atopic dermatitis stems from inherited abnormalities in the skin barrier, particularly in filaggrin expression. Abnormalities in filaggrin, a protein crucial for skin integrity, are associated with severe and persistent eczema.
In atopic dermatitis, there’s often an imbalance in T Helper lymphocytes, with an excess of Th-2 cells. These cells, along with associated chemical messengers like cytokines, contribute to barrier dysfunction and increased susceptibility to irritants and allergens.
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