The Inherited Barrier Defect
Causes of Atopic dermatitis
Studies indicate that inflammation in atopic dermatitis stems from inherited abnormalities in the skin barrier, particularly in filaggrin expression. Abnormalities in filaggrin, a protein crucial for skin integrity, are associated with severe and persistent eczema.
In atopic dermatitis, there’s often an imbalance in T Helper lymphocytes, with an excess of Th-2 cells. These cells, along with associated chemical messengers like cytokines, contribute to barrier dysfunction and increased susceptibility to irritants and allergens.
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